Workshop on PK/PD

Date: November 23rd, 2017

Location: Hilton Congress Centre, Groenplaats, Antwerp, Belgium

Room: TBA

Program Chair: Prof Dr Jan J De Waele, University Hospital Ghent, Belgium

Duration: 120 min

Pax: 40

Price: 100 EUR

Comment: This workshop can only be booked when attending the IFAD2017 meeting on Nov 24-25, 2017, at Hilton Congress Centre, Groenplaats, Antwerp, Belgium

Background:
Antibiotics save lives and are essential for the practice of intensive care medicine. Adequate antibiotic treatment is closely related to outcome. However this is challenging in the critically ill, as their pharmacokinetic profile is markedly altered. Therefore, it is surprising that critical care physicians continue to rely on standard dosing regimens for every patient, regardless of the actual clinical situation. At present, therapeutic drug monitoring may be of help, but has major disadvantages, remains unavailable for most antibiotics and has produced mixed results. Antibiotic dosing regimens are usually based on data from healthy volunteers with normal physiology or non-critically ill patients. However, in critically ill hospitalized patients, pathophysiological changes may have profound effects on the primary determinants of the pharmacokinetics (PK) of hydrophilic antibiotics which are distributed to interstitial fluid and that are predominantly excreted via the kidneys (like β-lactams, aminoglycosides, glycopeptides). Extravascular volume expansion with fluid loading in the setting of capillary leak (poor source control) may alter their volume of distribution (Vd), while changes in renal function can significantly influence drug clearance (Cl). The β-lactams are the most commonly prescribed antibiotics in the critically ill. Since bacterial killing is considered time-dependent, the pharmacodynamic (PD) parameter of interest is the fraction of time that the free drug concentration exceeds a minimum inhibitory concentration (MIC tested in vitro) of the causative microorganism – the fT>MIC.

Picture courtesy adamondemand

Learning objective: This workshop will outline the basic pharmacokinetic and pharmacodynamic principles that underlie the need for individualized and personalized drug dosing.

Draft scientific program (20min presentation with 10min for discussion)

1. PK/PD of antimicrobials in the ICU – Isabel Spriet, Leuven, Belgium
2. The impact of extracorporeal therapies – Fabio Taccone, Brussels, Belgium
3. Antibiotic therapeutic drug monitoring (TDM) – ready for prime time? – Jan De Waele, Ghent, Belgium
4. How to integrate big data in antibiotic therapy – Paul Elbers, Amsterdam, The Netherlands

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